1. Although, though, even though          +          clause

  • Although you don’t like her, you can be nice to her.
  • You can be nice to her although you don’t like her.

If the subordinate clause comes first, we must separate it with a comma. If the subordinate clause comes second, there is no comma.

  • Even though they have a car, they seldom use it.
  • They have a car though they seldom use it. (though is more common in spoken English, and is often used at the end of a sentence)
  • They have a car. They seldom use it, though. (even more conversational)

2. In spite of/despite          +         noun or -ing form

  • In spite of/despite having a car, they seldom use it.

Note:

   In spite of the fact that          +          clause

  • In spite of the fact that they have a car, they seldom use it.

 in spite of the fact that works as a coordinating conjunction. Therefore, it is used to connect two independent clauses and a comma is required.. 

3. While/whereas/but/ on the other hand/ yet/still/on the contrary        +     clause

  • He is very hardworking, while his wife is rather lazy.
  • Whereas Jane is very popular among her classmates, nobody likes her sister.
  • He wasn’t tired, yet he was sleeping very well.
  • The salary is very good. Still, the job itself is really boring.

4. However/nevertheless         +      clause

Both are formal; nevertheless is even more formal.

  • She denies it; nevertheless, nobody believes her.
  • She doesn’t like her; however, he is married to her.
  • The job was very demanding. However, the pay was very good.

Note:

Use a semicolon before and a comma after ‘however/nevertheless’ if you are writing a compound sentence. If ‘however/nevertheless’ is used to begin a sentence, it must be followed by a comma.

5. a) However/no matter how      +      adjective/adverb      +      clause   

We use it to say that it makes no difference how much/many/good/bad/ difficult/hard/well/interesting etc something is, or how much there is of something, or how long something takes, etc.

  • However much she loves you, she’ll never forgive you.
  • I couldn’t change his mind, however hard I tried.
  • No matter how late he comes, she’ll be waiting.
  • However many times the teacher explains things, he never understands.
  • However badly she treated her children, they loved her.
  • I must finish the report, however long it takes.
  • However much money he earns, she can spend it on clothes.

5. b) However/whoever/wherever/whatever/whenever/whichever       +      clause

No matter how/however   (in any way)  

No matter who/whoever  (any person)                      

No matter where/wherever   (any place)

No matter what/whatever     (any thing)

No matter when/whenever  (any time)

No matter which/whichever   (anyone from a limited set)

  • No matter who may come/whoever may come, tell him I am out.
  • No matter where you may hide it/wherever you (may) hide it, I’ll find it.
  • No matter what he did/whatever he did, she didn’t like it.
  • No matter who/whoever breaks the law, they will be punished.
  • No matter what/whatever happens in the future, I won’t leave you.

Note:

The same rule applies as for time and conditional clauses, so do not use will in this type of clause.

6. Adjective/adverb      +      as/though      +      clause

  • Late though it was, I had to talk to him.
  • Much as she likes him, she doesn’t trust him.
  • Hard as I tried, I couldn’t change his mind.
  • Tired though he was, he went to meet her at the bus stop.
  • Cold as the weather was, we enjoyed walking the dog.
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